Takemoto Y
Department of Physiology, Hiroshima University School of Medicine, Minami-ku, Japan.
Jpn J Physiol. 1995;45(5):759-69. doi: 10.2170/jjphysiol.45.759.
The cardiovascular effects of the centrally injected D-arginine were investigated in the conscious rat chronically instrumented with cisternal, arterial, and venous cannulae, as well as an electromagnetic flow probe around the superior mesenteric artery, renal artery, or terminal aorta (hindquarter). Intracisternal injection of D-arginine (10 mumol) increased arterial blood pressure and hindquarter flow lasting for 60 min or more. Previous injection of the beta-adrenoceptor blocker, propranolol (2 mg/kg, I.V.), markedly attenuated the hindquarter vasodilation caused by D-arginine; this response suggests the release of adrenaline. Peripheral resistance, calculated as arterial pressure divided by regional flow, increased in both the superior mesenteric artery (60%) and the renal artery (45%) 5 min after intracisternal injection of D-arginine. In the hindquarter, however, peripheral resistance decreased by 35% and arterial pressure increased by 25%. The pressor effect was significantly attenuated by producing ganglionic blockade with chlorisondamine (5 mg/kg, I.V.). The total peripheral blood flow increased from 12.9 to 15.9 ml/min/100 g body weight. This response indicates that the pressor effect of D-arginine is due to an increase of cardiac output rather than of peripheral resistance. Centrally administered D-arginine appears to activate the sympatho-adrenal system, especially the release of adrenaline.
在长期植入脑池、动脉和静脉插管以及肠系膜上动脉、肾动脉或终末主动脉（后肢）周围电磁血流探头的清醒大鼠中，研究了脑室内注射D-精氨酸的心血管效应。脑室内注射D-精氨酸（10 μmol）可使动脉血压和后肢血流增加，持续60分钟或更长时间。先前静脉注射β-肾上腺素能受体阻滞剂普萘洛尔（2 mg/kg）可显著减弱D-精氨酸引起的后肢血管舒张；这种反应提示肾上腺素的释放。脑室内注射D-精氨酸5分钟后，肠系膜上动脉（60%）和肾动脉（45%）的外周阻力（以动脉压除以局部血流计算）增加。然而，在后肢，外周阻力降低了35%，动脉血压升高了25%。用氯异吲哚铵（5 mg/kg，静脉注射）产生神经节阻断可显著减弱升压作用。总外周血流量从12.9增加到15.9 ml/min/100 g体重。这一反应表明，D-精氨酸的升压作用是由于心输出量增加而非外周阻力增加所致。脑室内给予D-精氨酸似乎激活了交感-肾上腺系统，尤其是肾上腺素的释放。
