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[保加利亚胰岛素制剂中胰高血糖素的放射免疫测定]

[Radioimmunological determination of glucagon in Bulgarian insulin substances].

作者信息

Dimitrova F, Sirakov L

机构信息

Department of Chemistry and Biochemistry, Higher Medical School, Sofia.

出版信息

Eksp Med Morfol. 1994;32(1-2):3-13.

PMID:8713345
Abstract

The contents of glucagon in insulin substances ("Pharmachim" Ltd.) is determined in accordance to the needs of pharmaceutical production. The middle quantitative values and standart deviation are specified. Nevertheless that monocomponent and bovine conventional insulin substances pertain to groups of different purity they exibit the highest purity. Bovine conventional insulins exibit the greatest variability, while monocomponent insulins are destinctively homogenous. Single-peak insulin substances exhibit less purity, but this group is more homogenous. The middle quantitative value is within the admissible limitations. Porcine conventional insulins have high contents of glucagon as well as high values of standard deviation.

摘要

按照药品生产需求测定胰岛素类物质(“Pharmachim”有限公司)中胰高血糖素的含量。规定了中间定量值和标准差。尽管单组分胰岛素和牛常规胰岛素属于不同纯度组,但它们的纯度最高。牛常规胰岛素的变异性最大,而单组分胰岛素明显更均匀。单峰胰岛素物质的纯度较低,但该组更均匀。中间定量值在允许范围内。猪常规胰岛素的胰高血糖素含量高,标准差也高。

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