Shinohara H, Niio Y, Hasebe S, Matsuoka S, Obuchi M, Higashi T S, Yamada M, Takagi T, Takizawa K, Honda M, Kuniyasu Y
Department of Radiology, Showa University, Fujigaoka Hospital, Japan.
Nihon Igaku Hoshasen Gakkai Zasshi. 1996 Feb;56(3):125-31.
The use of numerical integration method (N. INT) was evaluated in determining parameters by two-compartment model analysis from liver scintigraphy. Among the 15 subjects, 14 had liver cirrhosis or chronic hepatitis, and one was normal. When using N.INT, the sum of two exponential functions on heart regression curve following intravenous injection of 99mTc-galactosyl human serum albumin (99mTc-GSA) was promptly calculated. The parameters obtained from N.INT, including transfer rate of 99mTc-GSA from extrahepatic blood to liver (k1), dissociation rate from liver to extrahepatic blood (k2), and excretion rate from liver to gallblader (k3), were significantly correlated with those obtained by the nonlinear least square method (NLS). k1/k2 was related with the maximum removal rate of 99mTc-GSA obtained from nonlinear five compartment model analysis (r2 = 0.705, n = 15) and also with the severity score of liver disease as classified by the First Department of Surgery, Mie University Medical School (r2 = 0.686, n = 13). In terms of the time required to obtain these parameters, including the blood retention rate of 99mTc-GSA at 15 min after injection (%ID15), N.INT was faster than the traditional method (NLS).
通过肝脏闪烁扫描的两室模型分析来评估数值积分法（N.INT）在确定参数方面的应用。在15名受试者中，14人患有肝硬化或慢性肝炎，1人正常。使用N.INT时，静脉注射99mTc-半乳糖基人血清白蛋白（99mTc-GSA）后，能迅速计算出心脏回归曲线上两个指数函数的总和。从N.INT获得的参数，包括99mTc-GSA从肝外血液到肝脏的转移率（k1）、从肝脏到肝外血液的解离率（k2）以及从肝脏到胆囊的排泄率（k3），与通过非线性最小二乘法（NLS）获得的参数显著相关。k1/k2与从非线性五室模型分析获得的99mTc-GSA的最大清除率相关（r2 = 0.705，n = 15），也与三重大学医学院第一外科分类的肝病严重程度评分相关（r2 = 0.686，n = 13）。就获得这些参数所需的时间而言，包括注射后15分钟时99mTc-GSA的血液滞留率（%ID15），N.INT比传统方法（NLS）更快。
