β-肾上腺素能化合物的选择性。IV. 对1-（4'-甲基苯基）-2-异丙氨基丙醇的研究
[Selectivity of beta-adrenergic compounds. IV. Studies on 1-(4'-methylphenyl)-2-isopropylaminopropanol].
作者信息
Lucchelli A, Grana E, Zonta F
出版信息
Farmaco Sci. 1977 Jun;32(6):438-44.
PMID:872923
Abstract
The beta-adrenergic activity of 1-(4'-methylphenyl)-2-isopropylaminopropanol (H 35/25) was studied on isolated preparations (guinea pig atria, guinea pig and calf tracheal muscle, mouse cecum). H 35/25 shows variations in both affinity and intrinsic activity at the various levels tested. The discussion shows that this cannot be used as a means of characterizing beta-adrenergic receptors.
摘要
研究了1-(4'-甲基苯基)-2-异丙氨基丙醇（H 35/25）对离体标本（豚鼠心房、豚鼠和小牛气管肌肉、小鼠盲肠）的β-肾上腺素能活性。H 35/25在测试的各个水平上均表现出亲和力和内在活性的变化。讨论表明，这不能用作表征β-肾上腺素能受体的手段。
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