Huang Y T
Department of Biochemistry, Tongji Medical University, Wuhan.
Sheng Li Ke Xue Jin Zhan. 1996 Jan;27(1):25-30.
Lipoprotein (a) (Lp(a)) is a LDL-like lipoprotein with an additional highly polymorphic glycoprotein--apolipoprotein (a) (apo(a)). Apo(a) bears great homology with plasminogen. Lp(a) is synthesized by liver and its degradation may be carried out by a nonspecific process. Apo(a) isoform size and plasma Lp(a) levels are mainly determined by apo(a) gene. Lp(a) can easily be deposited in arterial wall. It promotes growth of smooth muscle cells and inhibits fibrinolysis. These could be the mechanisms by which Lp(a) accelerates atherosclerosis and thrombosis. The physiological role of Lp(a) has not been clearly understood.
脂蛋白(a)（Lp(a)）是一种类似低密度脂蛋白（LDL）的脂蛋白，带有一种额外的高度多态性糖蛋白——载脂蛋白(a)（apo(a)）。apo(a)与纤溶酶原具有高度同源性。Lp(a)由肝脏合成，其降解可能通过非特异性过程进行。apo(a)异构体大小和血浆Lp(a)水平主要由apo(a)基因决定。Lp(a)很容易沉积在动脉壁中。它促进平滑肌细胞生长并抑制纤维蛋白溶解。这些可能是Lp(a)加速动脉粥样硬化和血栓形成的机制。Lp(a)的生理作用尚未完全明确。
