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多发性硬化症的药物治疗:对新斯科舍省老年人的一项研究。

Drug therapy in multiple sclerosis: a study of Nova Scotia senior citizens.

作者信息

Sketris I S, Brown M, Murray T J, Fisk J D, McLean K

机构信息

College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada.

出版信息

Clin Ther. 1996 Mar-Apr;18(2):303-18; discussion 302. doi: 10.1016/s0149-2918(96)80012-9.

Abstract

We conducted a study to determine the types and costs of drugs used by Nova Scotia senior citizens with multiple sclerosis (MS) compared with the types and costs of drugs used by all senior citizens in Nova Scotia. Administrative claims databases from the Nova Scotia Seniors Pharmacare program for persons aged 65 years or older were linked to the Dalhousie Multiple Sclerosis Research Unit (DMSRU) clinical database (1980-1994). Analyses compared persons with MS aged 65 years or older who attended the DMSRU at least once with the general population of senior citizens. Not all persons with MS attended the DMSRU. In aggregate, Pharmacare costs in 1993-1994 for patients with MS aged 65 years or older (N = 52) were $975.00 Canadian per capita compared with $590.00 Canadian for all senior citizens in Nova Scotia (N = 108,646). Thus average drug costs for the senior citizens with MS were 65% greater than those for all senior citizens covered by Nova Scotia's comprehensive, publicly funded Pharmacare program. Compared with other senior citizens, those with MS more frequently received alpha-blockers, anticholinergics, cholinergics, tricyclic antidepressants, anticonvulsants, antifatigue agents, antispasticity agents, and antibiotics for bladder infections.

摘要

我们开展了一项研究,以确定新斯科舍省患有多发性硬化症(MS)的老年人所使用药物的类型和成本,并与新斯科舍省所有老年人所使用药物的类型和成本进行比较。新斯科舍省老年人药物护理计划中65岁及以上人群的行政索赔数据库与达尔豪斯多发性硬化症研究单位(DMSRU)临床数据库(1980 - 1994年)相链接。分析比较了至少去过一次DMSRU的65岁及以上MS患者与老年人群体。并非所有MS患者都去过DMSRU。总体而言,1993 - 1994年,65岁及以上MS患者(N = 52)的药物护理成本人均为975.00加元,而新斯科舍省所有老年人(N = 108,646)的人均成本为590.00加元。因此,患有MS的老年人的平均药物成本比新斯科舍省全面的公共资助药物护理计划覆盖的所有老年人的平均药物成本高65%。与其他老年人相比,患有MS的人更频繁地使用α受体阻滞剂、抗胆碱能药物、胆碱能药物、三环类抗抑郁药、抗惊厥药、抗疲劳药、抗痉挛药以及用于治疗膀胱感染的抗生素。

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