豚鼠和大鼠脑中5-CT不敏感的5-HT1样识别位点的放射自显影定位。
Autoradiographic localization of 5-CT-insensitive 5-HT1-like recognition sites in guinea pig and rat brain.
作者信息
Stanton J A, Middlemiss D N, Beer M S
机构信息
Merck, Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, UK.
出版信息
Neuropharmacology. 1996 Feb;35(2):223-9. doi: 10.1016/0028-3908(95)00178-6.
Quantitative autoradiographic studies, with [3H]5-HT, were used to investigate the distribution of 5-CT-insensitive 5-HT1-like (5-HT1E/1F) recognition sites in rat and guinea pig brain. For comparison and control purposes the distribution of the closely related 5-HT1D binding site, which is abundant in the guinea pig but not the rat, was also investigated, as well as total specific [3H]5-HT binding. Results from this study confirm the previously described regional distribution of the 5-HT1D binding site and also revealed a predominance of 5-CT-insensitive 5-HT1-like 5-HT1E/1F) recognition sites in the olfactory tubercle, caudate putamen, nucleus accumbens and substantia nigra of both species. Interestingly 5-CT-insensitive 5-HT1-like (5-HT1E/1F) recognition sites were particularly dense in the claustrum of the guinea pig, but not the rat.
采用[3H]5-羟色胺进行定量放射自显影研究，以调查大鼠和豚鼠脑中对5-羧色胺不敏感的5-羟色胺1样（5-HT1E/1F）识别位点的分布。为了进行比较和对照，还研究了密切相关的5-HT1D结合位点的分布，该位点在豚鼠中丰富而在大鼠中不存在，同时也研究了总的特异性[3H]5-羟色胺结合。本研究结果证实了先前描述的5-HT1D结合位点的区域分布，并且还揭示了在两个物种的嗅结节、尾状壳核、伏隔核和黑质中，对5-羧色胺不敏感的5-羟色胺1样（5-HT1E/1F）识别位点占优势。有趣的是，对5-羧色胺不敏感的5-羟色胺1样（5-HT1E/1F）识别位点在豚鼠的屏状核中特别密集，而在大鼠中则不然。
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