Hennig W
Department of Molecular and Developmental Genetics, Catholic University, Nijmegen, The Netherlands.
Int J Dev Biol. 1996 Feb;40(1):167-76.
A short summary on the present knowledge on spermatogenesis in Drosophila is given which also points out particular questions of interest in the context of this morphogenetic process. Such points of interest are the formation of lampbrush loops in primary spermatocytes, the chromosomal events during meiosis, the occurrence of chromatin rearrangements and the regulation of gene activities at the posttranscriptional level. The activities and some major conclusions from my laboratory are subsequently described. They include studies of the expression of histone variants, the structure and function of lampbrush loops and the expression of genes participating in sperm morphogenesis.
本文给出了关于果蝇精子发生的现有知识的简短总结,同时也指出了在这个形态发生过程中特别值得关注的问题。这些值得关注的点包括初级精母细胞中灯刷环的形成、减数分裂期间的染色体事件、染色质重排的发生以及转录后水平上基因活性的调控。随后描述了我实验室的研究活动和一些主要结论。这些研究包括组蛋白变体表达的研究、灯刷环的结构和功能以及参与精子形态发生的基因的表达。