Büchi E R, Kurosawa A, Tso M O
M.O.M. Tso Eye Pathology Laboratory, UIC Eye Center, Chicago, IL 60612, USA.
Graefes Arch Clin Exp Ophthalmol. 1996 Jun;234(6):388-98. doi: 10.1007/BF00190716.
No satisfactory primate model of diabetic retinopathy has been produced. The clinical picture of microangiopathic retinopathy in diabetic hypertensive monkeys has been previously reported. The present study describes the pathologic findings of these animals.
Eleven eyes of six monkeys (five rhesus, one cynomolgus) were studied. Diabetes mellitus was either spontaneous or induced by streptozocin; mild arterial hypertension was either spontaneous or induced by fludrocortisone acetate. In two monkeys, the horseradish peroxidase tracer technique was employed. Trypsin flat preparations of the nasal retinal vasculature were prepared. The material was studied by light and electron microscopy.
We divided the development of the microangiopathic retinopathy into three stages. In the early stage, background retinopathy was characterized by microvascular abnormalities and capillary dropout. Massive vascular leakage, intraretinal exudates and hemorrhage, cystoid degeneration, and cotton-wool spots were features of an exudative retinopathy in the second stage. In the final stage, chronic ischemic retinopathy was characterized by vascular occlusions and areas of retinal atrophy.
Microangiopathic retinopathy in diabetic monkeys with mild hypertension presented many features of human diabetic and hypertensive retinopathy, except vitreous neovascularization.
尚未建立令人满意的糖尿病视网膜病变灵长类动物模型。先前已报道过糖尿病高血压猴微血管性视网膜病变的临床表现。本研究描述了这些动物的病理发现。
对6只猴子（5只恒河猴，1只食蟹猴）的11只眼睛进行了研究。糖尿病为自发性或由链脲佐菌素诱导产生；轻度动脉高血压为自发性或由醋酸氟氢可的松诱导产生。对2只猴子采用了辣根过氧化物酶示踪技术。制备了鼻侧视网膜血管系统的胰蛋白酶扁平标本。材料经光镜和电镜研究。
我们将微血管性视网膜病变的发展分为三个阶段。早期，背景性视网膜病变的特征为微血管异常和毛细血管缺失。大量血管渗漏、视网膜内渗出和出血、囊样变性以及棉絮斑是第二阶段渗出性视网膜病变的特征。在最后阶段，慢性缺血性视网膜病变的特征为血管闭塞和视网膜萎缩区域。
伴有轻度高血压的糖尿病猴的微血管性视网膜病变呈现出人类糖尿病和高血压性视网膜病变的许多特征，但无玻璃体新生血管形成。
