Simola M, Böss I, Holopainen E, Malmberg H, Ruoppi P, Seppä J, Siivonen L, Suonpää J, Piepponen T
Department of Otorhinolaryngology, University Central Hospital, Helsinki, Finland.
Rhinology. 1996 Mar;34(1):21-3.
The efficacy and side effects of once-daily astemizole-D, a combination of 10 mg astemizole and 240 mg pseudoephedrine, were compared with those of twice-daily brompheniramine-D, a combination of 12 mg brompheniramine and 50 mg phenylpropanolamine (Lunerin), in 64 patients with seasonal allergic rhinitis caused by birch pollen. Efficacy was monitored by patient's diary scores, investigator assessments of nasal and eye symptoms and need of rescue medication during the 4-week study period. Both astemizole-D and brompheniramine-D reduced nasal and eye symptoms of allergy. There were no significant differences between the treatment groups regarding obstruction, but brompheniramine-D alleviated symptoms of rhinorrhoea and itchy eyes significantly more than astemizole-D. On the other hand, the patients in the brompheniramine-D group reported dry mouth, tiredness and drowsiness more often than those in the astemizole-D group. The results indicate that the two drugs are effective in the treatment of seasonal allergic rhinitis, but astemizole-D is better tolerated than brompheniramine-D.
将10毫克阿司咪唑与240毫克伪麻黄碱制成的复方制剂阿司咪唑-D（astemizole-D）每日一次的疗效及副作用，与由12毫克溴苯那敏和50毫克苯丙醇胺（Lunerin）制成的复方制剂溴苯那敏-D（brompheniramine-D）每日两次的疗效及副作用，在64例由桦树花粉引起的季节性变应性鼻炎患者中进行了比较。在为期4周的研究期间，通过患者的日记评分、研究者对鼻和眼症状的评估以及使用急救药物的需求来监测疗效。阿司咪唑-D和溴苯那敏-D均减轻了过敏的鼻和眼症状。治疗组之间在鼻塞方面无显著差异，但溴苯那敏-D比阿司咪唑-D更能显著减轻鼻漏和眼痒症状。另一方面，溴苯那敏-D组的患者比阿司咪唑-D组的患者更常报告口干、疲倦和嗜睡。结果表明，这两种药物在治疗季节性变应性鼻炎方面均有效，但阿司咪唑-D比溴苯那敏-D耐受性更好。
