环孢素A对小鼠实验性自身免疫性甲状腺炎（EAT）甲状腺功能的影响。
Influence of cyclosporine A on thyroid function in the experimental autoimmune thyroiditis (EAT) in mice.
作者信息
Czyzyk J K, Jakóbisiak M
机构信息
Department of Histology and Embryology, Institute of Biostructure, Medical Academy, Warsaw, Poland.
出版信息
Arch Immunol Ther Exp (Warsz). 1995;43(1):55-9.
We have examined the influence of cyclosporine A (CsA) on thyroid gland function during development of experimental autoimmune thyroiditis (EAT) in CBA (H-2k) mice, delivering the agent in different regimens and doses, either as commercial intravenous preparation or encapsulated into liposomes. The evaluation of autoimmunity was done by the assessment of serum concentration of thyroxine (T4). We showed that a high dose CsA (360 mg/kg) prevented the development of thyroid deficiency whereas a small dose (25-60 mg/kg) potentiated the decrease of T4 serum level. Moreover, we found that the same dose of CsA enclosed in liposomes and of its commercial preparation can have different effect on T4 level in mice with EAT.
我们研究了环孢素A（CsA）对CBA（H-2k）小鼠实验性自身免疫性甲状腺炎（EAT）发展过程中甲状腺功能的影响，以不同方案和剂量给药，剂型为市售静脉制剂或包裹于脂质体中。通过评估血清甲状腺素（T4）浓度来评价自身免疫性。我们发现，高剂量的CsA（360mg/kg）可预防甲状腺功能减退的发生，而低剂量（25-60mg/kg）则会增强血清T4水平的降低。此外，我们还发现，相同剂量包裹于脂质体中的CsA及其市售制剂对EAT小鼠的T4水平可产生不同影响。
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