降脂治疗：对内皮功能障碍的影响

Lipid-lowering treatment: effects on endothelial dysfunction.

作者信息

Rubba P, Mancini M

机构信息

Institute of Internal Medicine and Diseases of Metabolism, Medical School, Federico II University, Naples, Italy.

出版信息

Curr Opin Lipidol. 1995 Dec;6(6):348-53. doi: 10.1097/00041433-199512000-00003.

DOI:10.1097/00041433-199512000-00003

PMID:8750246

Abstract

An association has been demonstrated between the extent of atherosclerotic involvement and vasodilatory capacity in coronary and cerebral circulation. Impairment of endothelium-dependent relaxation is inversely related to HDL concentrations in plasma. Angiographic studies in humans have shown improved vasodilation capacity of the coronary arteries after lipid-lowering treatment.

摘要

动脉粥样硬化累及范围与冠状动脉和脑循环中的血管舒张能力之间已证实存在关联。内皮依赖性舒张功能受损与血浆中高密度脂蛋白（HDL）浓度呈负相关。人体血管造影研究表明，降脂治疗后冠状动脉的血管舒张能力有所改善。