Matsubara H, Fujishima S, Sayama K, Akasaka Y, Yamasawa F, Ishizaka A, Yamaguchi K, Kanazawa M
Department of Medicine, School of Medicine, Keio University, Tokyo, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1996 May;34(5):552-6.
A 75-year-old man was admitted to the hospital due to acute onset of a dry cough and dyspnea on exertion. Arterial blood gas analysis showed hypoxemia (PaO2 = 63 Torr) on room air. Chest radiography and computed tomography showed diffuse bilateral infiltrates. Adult respiratory distress syndrome was diagnosed from the findings described above and from the lack of evidence of left heart failure. Diffuse alveolar damage was confirmed at autopsy. During the course of his illness, the patient underwent bronchoalveolar lavage five times. The recovered fluid had high concentrations of interleukin-8 (IL-8), with a maximum of 6260 pg/ml and a minimum of 190 pg/ml, and these values correlated with the number of polymorphonuclear cells in the fluid. Levels of leukotriene B4, another chemotactic factor for PMN, in the lavage fluid were not high. We conclude that IL-8 was a major chemoattractant for PMN in the alveoli of this patient.
一名75岁男性因突发干咳和劳力性呼吸困难入院。动脉血气分析显示在室内空气中存在低氧血症（动脉血氧分压=63托）。胸部X线摄影和计算机断层扫描显示双侧弥漫性浸润。根据上述表现以及缺乏左心衰竭的证据，诊断为成人呼吸窘迫综合征。尸检证实存在弥漫性肺泡损伤。在患病过程中，该患者接受了5次支气管肺泡灌洗。回收液中白细胞介素-8（IL-8）浓度很高，最高为6260皮克/毫升，最低为190皮克/毫升，这些值与灌洗液中多形核细胞数量相关。灌洗液中另一种中性粒细胞趋化因子白三烯B4的水平不高。我们得出结论，IL-8是该患者肺泡中中性粒细胞的主要趋化因子。
