Yoshimi M, Takayama K, Aizawa H, Inoue H, Hashiguchi N, Murakami J, Hasuo K, Hara N
Research Institute for Diseases of the Chest Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1996 May;34(5):569-74.
A 63-year-old man was referred to our hospital for evaluation and treatment of severe dyspnea on exertion which had persisted for a few years. He presented with cyanosis and markedly clubbed fingers, and laboratory data disclosed hypoxemia, polycythemia, and liver dysfunction. A chest X-ray film showed increased vascular markings in both lower lung fields. Arterial blood gas analysis showed severe hypoxemia, with a PaO2 of 46 Torr and a PaCO2 of 31 Torr while the patient was breathing room air. The PaO2 increased only slightly with inhalation of 100% oxygen, which suggested the presence of a large R-L shunt. The hepatopulmonary syndrome was diagnosed. Angiography of the pulmonary artery revealed a large pulmonary arterio-venous fistula with markedly dilated arteries in both lower lobes. Transarterial embolization was done three times with a total of 62 metal coils. There were no complications. Embolization reduced the shunt from 56% to 31%, increased the PaO2, and relieved the dyspnea. Pulmonary artery embolization can be useful in treating pulmonary arterio-venous fistulas associated with the hepatopulmonary syndrome.
一名63岁男性因劳力性重度呼吸困难持续数年而转诊至我院进行评估和治疗。他出现了发绀和明显的杵状指,实验室检查显示低氧血症、红细胞增多症和肝功能障碍。胸部X线片显示双下肺野血管纹理增多。动脉血气分析显示严重低氧血症,患者呼吸空气时,动脉血氧分压(PaO2)为46托,动脉血二氧化碳分压(PaCO2)为31托。吸入100%氧气时,PaO2仅略有升高,提示存在大量右向左分流。诊断为肝肺综合征。肺动脉造影显示一个大的肺动静脉瘘,双下叶动脉明显扩张。经动脉栓塞术进行了3次,共使用62个金属线圈。无并发症发生。栓塞使分流从56%降至31%,提高了PaO2,并缓解了呼吸困难。肺动脉栓塞术可用于治疗与肝肺综合征相关的肺动静脉瘘。