Gutiérrez-Larraya Aguado F, Galindo Izquierdo A, Olaizola Llodio I, Velasco Bayón J M, Merino Batres G, de la Fuente P
Departamento de Pediatría, Facultad de Medicina, Universidad Complutense, Hospital Materno-Infantil 12 de Octubre, Madrid.
Rev Esp Cardiol. 1996 Jun;49(6):444-50.
Fetal supraventricular tachycardia is an infrequent and difficult to manage disease. Several therapeutic approaches have been proposed. We report our experience in its diagnosis and management.
Evaluation of the clinical features of fetal supraventricular tachycardia and efficacy of maternal and fetal medications in use for treatment. Immediate neonatal evolution is commented on. A therapeutic schema is proposed.
Nineteen fetuses with echocardiographically (M-mode and/or Doppler two dimensionally oriented) supraventricular tachycardia were diagnosed.
Mean gestational age was 32 weeks; 8 fetuses had developed hydrops; 3 patients had dilated cardiomyopathy (two of them were hydropic). Two cases were prenatally diagnosed as atrial flutter (both of them without hydrops). Sixteen fetuses received transplacentary treatment: 8 with digital, 6 more associated with flecainide, direct administration of amiodarone to the fetus was added in two cases. Three patients died during follow-up (one postnatally, at third week of life), all of them had developed hydrops; arrhythmia characteristics were unmodified in three and control of cardiac rhythm was achieved in ten cases.
In the majority of cases there are no cardiac malformations associated. It is possible to control the tachycardia, even if hydrops is present. It is not indicated to abbreviate the gestation. First election drugs are maternal digoxin and flecainide, they do not produce significant fetal or maternal secondary effects. Occasionally it is necessary to add or to change to other drugs or to propose more aggressive approaches.
胎儿室上性心动过速是一种罕见且难以处理的疾病。已经提出了几种治疗方法。我们报告我们在其诊断和处理方面的经验。
评估胎儿室上性心动过速的临床特征以及用于治疗的母体和胎儿药物的疗效。对新生儿的即刻转归进行评论。提出一种治疗方案。
19例经超声心动图(M型和/或二维定向多普勒)诊断为室上性心动过速的胎儿。
平均孕周为32周;8例胎儿出现水肿;3例患者有扩张型心肌病(其中2例有水肿)。2例产前诊断为心房扑动(均无水肿)。16例胎儿接受了经胎盘治疗:8例使用地高辛,6例加用氟卡尼,2例加用直接向胎儿给药的胺碘酮。3例患者在随访期间死亡(1例在出生后,生命的第三周),均有水肿;3例心律失常特征未改变,10例实现了心律控制。
在大多数情况下,不存在相关的心脏畸形。即使存在水肿,也有可能控制心动过速。不建议提前终止妊娠。首选药物是母体使用的地高辛和氟卡尼,它们不会产生明显的胎儿或母体副作用。偶尔有必要加用或换用其他药物或采取更积极的方法。