Sotnikov V M, Kharchenko V P, Pan'shin G A, Galil-Ogly G A, Zhdanov G P, Zakharova L V, Teĭblium M M, Tolchinskiĭ B I
Vestn Rentgenol Radiol. 1996 Mar-Apr(2):26-9.
The remission rates were analysed during radiation and chemoradiation treatments and chemotherapy of 255 patients with low-grade generalized non-Hodgkin's lymphomas. Complete remission was achieved in 15.3% of patients, partial remission was in 82.4%. No effect was seen in 2.3% of patients. The rate of complete remissions was 4.2% for radiation treatment, 29.5% for chemoradiation, and 10.6% for chemotherapy. Chemoradiation treatment regimen was the most effective for this group of patients, in all morphological types and chiefly in Stage III. The intensified chemoradiation regimen improves the immediate outcome of treatment; a combination of series polychemotherapy with radiation applied to all diseased lymphatic collectors in a cumulative radiation dose of 30-40 Gy. The effect of the chemoradiation regimen is virtually completely revealed in the combination of three series of polychemotherapy and radiation therapy; the continued chemotherapy does not increase the rate of complete remissions.
对255例低度全身性非霍奇金淋巴瘤患者在放疗、放化疗及化疗期间的缓解率进行了分析。15.3%的患者实现完全缓解,82.4%的患者部分缓解。2.3%的患者未见疗效。放疗的完全缓解率为4.2%,放化疗为29.5%,化疗为10.6%。放化疗方案对该组患者最为有效,适用于所有形态学类型,主要是Ⅲ期患者。强化放化疗方案改善了治疗的近期效果;系列多药化疗与放疗相结合,对所有病变淋巴引流区给予30 - 40 Gy的累积放疗剂量。放化疗方案的效果在三个系列的多药化疗与放疗联合应用时几乎完全显现;继续化疗并不会提高完全缓解率。