Jiang J, Struhl G
Howard Hughes Medical Institute Department of Genetics and Development Columbia University College of Physicians and Surgeons New York, New York 10032, USA.
Cell. 1996 Aug 9;86(3):401-9. doi: 10.1016/s0092-8674(00)80113-0.
Growth and patterning of the Drosophila leg are organized by three secreted proteins: Hedgehog (Hh), Wingless (Wg), and Decapentaplegic (Dpp). Hh is secreted by posterior cells; it acts at short range to induce dorsal anterior cells to secrete Dpp and ventral anterior cells to secrete Wg. Here we show that the complementary patterns of dpp and wg expression are maintained by mutual repression: Dpp signaling blocks wg transcription, whereas Wg signaling attenuates dpp transcription. We also show that this mutual repression is essential for normal axial patterning because it ensures that the dorsalizing and ventralizing activities of Dpp and Wg are restricted to opposite sides of the leg primordium and meet only at the center of the primordium to distalize the appendage.
刺猬蛋白（Hh）、无翅蛋白（Wg）和五体不全蛋白（Dpp）。Hh由后部细胞分泌；它在短距离内起作用，诱导背侧前部细胞分泌Dpp，腹侧前部细胞分泌Wg。我们在此表明，dpp和wg表达的互补模式通过相互抑制得以维持：Dpp信号传导阻断wg转录，而Wg信号传导减弱dpp转录。我们还表明，这种相互抑制对于正常的轴向模式形成至关重要，因为它确保了Dpp和Wg的背化和腹化活性仅限于腿部原基的相对两侧，并且仅在原基中心相遇以使附肢向远端生长。
