Bliss P, Parsons C A, Blake P R
Pelvic Unit, Royal Marsden Hospital, London.
Br J Radiol. 1996 Jun;69(822):548-54. doi: 10.1259/0007-1285-69-822-548.
Five patients out of a total of 183 treated with radical radiotherapy for carcinoma of cervix at The Royal Marsden Hospital from 1991 to 1994 inclusive have developed severe pelvic fractures. Two patients had rheumatoid arthritis, one of whom died as a result of the radiation induced damage. This patient developed radiological evidence of radionecrosis within 1 month of completing radiotherapy. There are very few reports in the literature of such a rapid onset. We suggest that the presence of a connective tissue disorder in a patient with other risk factors such as steroid use, old age and osteopenia should alert the clinician to the risk of radionecrosis following radical irradiation.
1991年至1994年（含）期间，在皇家马斯登医院接受宫颈癌根治性放疗的183名患者中，有5名发生了严重的骨盆骨折。两名患者患有类风湿性关节炎，其中一名因放疗引起的损伤而死亡。该患者在完成放疗后1个月内出现了放射性坏死的影像学证据。文献中关于如此快速发病的报道极少。我们认为，对于存在结缔组织疾病且伴有其他风险因素（如使用类固醇、老年和骨质减少）的患者，临床医生应警惕根治性放疗后发生放射性坏死的风险。
