Bravo E, Cantafora A, Marinelli T, Avella M, Mayes P A, Botham K M
Istituto Superiore di Sanita, Laboratory of Metabolism and Pathological Biochemistry, Rome, Italy.
Life Sci. 1996;59(4):331-7. doi: 10.1016/0024-3205(96)00302-5.
The effects of chylomicron remnants derived from corn oil (rich in n-6 polyunsaturated fatty acids) and palm oil (rich in long chain saturated fatty acids) on bile acid synthesis and very low density lipoprotein secretion in cultured rat hepatocytes were studied. Incubation of the cells with corn oil remnants led to increased bile acid production, while the secretion of lipid in very low density lipoprotein remained unchanged. In contrast, addition of palm oil remnants to the medium did not affect bile acid synthesis, but resulted in the secretion of cholesterol-rich very low density lipoprotein. These findings show that chylomicron remnants of different fatty acid composition have differential effects on cholesterol metabolism in liver cells, and provide part of the explanation for the hyper- and hypocholesterolaemic effects of saturated and polyunsaturated fatty acids.
研究了源自玉米油（富含n-6多不饱和脂肪酸）和棕榈油（富含长链饱和脂肪酸）的乳糜微粒残粒对培养的大鼠肝细胞中胆汁酸合成及极低密度脂蛋白分泌的影响。用玉米油残粒孵育细胞导致胆汁酸生成增加，而极低密度脂蛋白中的脂质分泌保持不变。相反，向培养基中添加棕榈油残粒不影响胆汁酸合成，但导致富含胆固醇的极低密度脂蛋白分泌。这些发现表明，不同脂肪酸组成的乳糜微粒残粒对肝细胞中的胆固醇代谢有不同影响，并为饱和脂肪酸和多不饱和脂肪酸的高胆固醇血症和低胆固醇血症作用提供了部分解释。
