Mann R S, Chan S K
Department of Biochemistry and Molecular Biophysics, Columbia University, NY 10032, USA.
Trends Genet. 1996 Jul;12(7):258-62. doi: 10.1016/0168-9525(96)10026-3.
For many DNA-binding transcription factors it is often difficult to reconcile their highly specific in vivo functions with their less specific in vitro DNA-binding properties. Cooperative DNA binding with cofactors often provides part of the answer to this paradox and recent studies have demonstrated this to be the case for the homeotic complex (HOX) family of transcription factors. However, the unique problem posed by these highly related and developmentally important transcription factors requires additional twists to the standard solution, which are beginning to become apparent from the characterization of the HOX cofactors encoded by the extradenticle and PBX genes.
对于许多DNA结合转录因子而言，常常难以使其高度特异的体内功能与其体外不太特异的DNA结合特性相协调。与辅因子的协同DNA结合通常为这一矛盾提供了部分答案，最近的研究表明同源异型复合体（HOX）转录因子家族就是这种情况。然而，这些高度相关且对发育至关重要的转录因子所带来的独特问题需要对标准解决方案进行额外的调整，从对由额外牙本质和PBX基因编码的HOX辅因子的表征中，这些调整开始变得明显。
