• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Induction of DT-diaphorase by 1,2-dithiole-3-thione and increase of antitumour activity of bioreductive agents.1,2-二硫杂环戊烯-3-硫酮诱导DT-黄递酶并增强生物还原药物的抗肿瘤活性。
Br J Cancer Suppl. 1996 Jul;27:S9-14.
2
Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents.1,2-二硫醇-3-硫酮对人肿瘤细胞和正常细胞中DT-黄递酶的诱导作用及其对生物还原药物抗肿瘤活性的影响。
Br J Cancer. 1998 Apr;77(8):1241-52. doi: 10.1038/bjc.1998.209.
3
Induction of DT-diaphorase in cancer chemoprevention and chemotherapy.DT-黄递酶在癌症化学预防和化疗中的诱导作用。
Oncol Res. 1997;9(6-7):371-82.
4
The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.功能基团对DT-黄递酶还原和激活醌类生物还原剂的影响。
Cancer Chemother Pharmacol. 2002 Feb;49(2):101-10. doi: 10.1007/s00280-001-0395-1. Epub 2001 Nov 24.
5
Factors influencing the induction of DT-diaphorase activity by 1,2-dithiole-3-thione in human tumor cell lines.1,2-二硫杂环戊烯-3-硫酮诱导人肿瘤细胞系中DT-黄递酶活性的影响因素
Biochem Pharmacol. 2001 Apr 15;61(8):955-64. doi: 10.1016/s0006-2952(01)00537-8.
6
Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9.国立癌症研究所肿瘤细胞系面板中的还原酶表达：与对丝裂霉素C和EO9敏感性的相关性
J Natl Cancer Inst. 1996 Mar 6;88(5):259-69. doi: 10.1093/jnci/88.5.259.
7
Enhanced cytotoxicity of mitomycin C in human tumour cells with inducers of DT-diaphorase.用 DT-黄递酶诱导剂增强丝裂霉素 C 对人肿瘤细胞的细胞毒性。
Br J Cancer. 1999 Jun;80(8):1223-30. doi: 10.1038/sj.bjc.6690489.
8
Development, pharmacology, role of DT-diaphorase and prospects of the indoloquinone EO9.吲哚醌EO9的研发、药理学、DT-黄递酶的作用及前景
Gen Pharmacol. 1996 Apr;27(3):421-9. doi: 10.1016/0306-3623(95)00118-2.
9
DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9.DT-黄递酶可保护细胞免受吲哚醌EO9的缺氧细胞毒性作用。
Br J Cancer. 1994 Dec;70(6):1136-43. doi: 10.1038/bjc.1994.461.
10
Relative importance of DT-diaphorase and hypoxia in the bioactivation of EO9 by human lung tumor cell lines.人肺肿瘤细胞系中DT-黄递酶和缺氧在EO9生物活化中的相对重要性。
Int J Radiat Oncol Biol Phys. 1994 May 15;29(2):295-9. doi: 10.1016/0360-3016(94)90278-x.

引用本文的文献

1
NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones.烟酰胺腺嘌呤二核苷酸（NAD(P)H）：醌氧化还原酶 1（NQO1）在抗肿瘤醌类药物的敏感性和耐药性中的作用。
Biochem Pharmacol. 2012 Apr 15;83(8):1033-40. doi: 10.1016/j.bcp.2011.12.017. Epub 2011 Dec 24.
2
Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo.通过饮食诱导NQO1可增强丝裂霉素C在人结肠肿瘤体内的抗肿瘤活性。
Br J Cancer. 2004 Oct 18;91(8):1624-31. doi: 10.1038/sj.bjc.6602171.
3
Enhanced cytotoxicity of mitomycin C in human tumour cells with inducers of DT-diaphorase.用 DT-黄递酶诱导剂增强丝裂霉素 C 对人肿瘤细胞的细胞毒性。
Br J Cancer. 1999 Jun;80(8):1223-30. doi: 10.1038/sj.bjc.6690489.
4
Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents.1,2-二硫醇-3-硫酮对人肿瘤细胞和正常细胞中DT-黄递酶的诱导作用及其对生物还原药物抗肿瘤活性的影响。
Br J Cancer. 1998 Apr;77(8):1241-52. doi: 10.1038/bjc.1998.209.

本文引用的文献

1
EO9: a novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models.EO9：一种新型的生物还原烷基化吲哚醌，在临床前模型中具有优先的实体瘤活性且无骨髓毒性。
Eur J Cancer. 1993;29A(6):897-906. doi: 10.1016/s0959-8049(05)80434-4.
2
Mitomycin therapy in gastric cancer.丝裂霉素在胃癌治疗中的应用
Oncology. 1993 Apr;50 Suppl 1:70-7. doi: 10.1159/000227249.
3
Reductive activation of mitomycin C by NADH:cytochrome b5 reductase.NADH：细胞色素b5还原酶对丝裂霉素C的还原激活作用。
Cancer Res. 1993 Oct 15;53(20):4907-12.
4
Experience with mitomycin in the treatment of non-small cell lung cancer.丝裂霉素治疗非小细胞肺癌的经验。
Oncology. 1993 Apr;50 Suppl 1:24-30. doi: 10.1159/000227244.
5
DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C.DT-黄递酶在醌类的激活与解毒过程中的作用。丝裂霉素C的生物还原激活作用。
Cancer Metastasis Rev. 1993 Jun;12(2):83-101. doi: 10.1007/BF00689803.
6
The experimental development of bioreductive drugs and their role in cancer therapy.生物还原药物的实验进展及其在癌症治疗中的作用。
Cancer Metastasis Rev. 1993 Jun;12(2):73-82. doi: 10.1007/BF00689802.
7
Cellular pharmacology of quinone bioreductive alkylating agents.醌生物还原烷基化剂的细胞药理学
Cancer Metastasis Rev. 1993 Jun;12(2):165-76. doi: 10.1007/BF00689808.
8
NAD(P)H:quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues.NAD(P)H：醌氧化还原酶1（DT-黄递酶）在正常组织和肿瘤组织中的表达
Cancer Metastasis Rev. 1993 Jun;12(2):103-17. doi: 10.1007/BF00689804.
9
The electrophile counterattack response: protection against neoplasia and toxicity.亲电体反击反应：对肿瘤形成和毒性的防护
Adv Enzyme Regul. 1993;33:281-96. doi: 10.1016/0065-2571(93)90024-8.
10
Studies with 1,2-dithiole-3-thione as a chemoprotector of hydroquinone-induced toxicity to DBA/2-derived bone marrow stromal cells.以1,2 - 二硫杂环戊烯 - 3 - 硫酮作为对苯二酚诱导的DBA/2来源骨髓基质细胞毒性的化学保护剂的研究。
Environ Health Perspect. 1993 Jun;101(2):172-7. doi: 10.1289/ehp.93101172.

1,2-二硫杂环戊烯-3-硫酮诱导DT-黄递酶并增强生物还原药物的抗肿瘤活性。

Induction of DT-diaphorase by 1,2-dithiole-3-thione and increase of antitumour activity of bioreductive agents.

作者信息

Begleiter A, Leith M K, Curphey T J

机构信息

Manitoba Institute of Cell Biology, Manitoba Cancer Treatment and Research Foundation, Winnipeg, Canada.

出版信息

Br J Cancer Suppl. 1996 Jul;27:S9-14.

PMID:8763837
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2150028/
Abstract

Bioreductive antitumour agents are an important new class of anticancer drugs that require activation by reduction. The two-electron reducing enzyme, DT-diaphorase, has been shown to be an important activating enzyme for the bioreductive agents, mitomycin C (MMC) and EO9. Incubation of L5178Y murine lymphoma cells in vitro with 1,2-dithiole-3-thione (D3T) increased the level of DT-diaphorase activity in these cells 22-fold. In contrast, D3T had no effect on the DT-diaphorase level in normal mouse bone marrow cells. Combination therapy with D3T and MMC or EO9, produced a 2- or 7-fold enhancement, respectively, of the cytotoxic activity of these antitumour agents in L5178Y cells. By comparison, D3T did not enhance the activity of MMC in marrow cells and produced only a small increase in EO9 cytotoxicity in these cells. The DT-diaphorase inhibitor, dicoumarol, inhibited the effect of D3T on the antitumour activity of the bioreductive agents, supporting the proposal that the enhanced anticancer activity was due to the elevated enzyme level. These findings suggest that D3T, or other inducers of DT-diaphorase, could be used to enhance the antitumour efficacy of bioreductive antitumour agents.

摘要

生物还原抗肿瘤药物是一类重要的新型抗癌药物，需要通过还原作用来激活。双电子还原酶DT-黄递酶已被证明是生物还原药物丝裂霉素C（MMC）和EO9的一种重要激活酶。在体外将L5178Y小鼠淋巴瘤细胞与1,2-二硫醇-3-硫酮（D3T）一起孵育，可使这些细胞中的DT-黄递酶活性水平提高22倍。相比之下，D3T对正常小鼠骨髓细胞中的DT-黄递酶水平没有影响。D3T与MMC或EO9联合治疗分别使这些抗肿瘤药物在L5178Y细胞中的细胞毒性活性提高了2倍或7倍。相比之下，D3T并没有增强MMC在骨髓细胞中的活性，并且在这些细胞中仅使EO9的细胞毒性略有增加。DT-黄递酶抑制剂双香豆素抑制了D3T对生物还原药物抗肿瘤活性的影响，支持了增强的抗癌活性是由于酶水平升高这一观点。这些发现表明，D3T或其他DT-黄递酶诱导剂可用于提高生物还原抗肿瘤药物的抗肿瘤疗效。