哺乳动物细胞对缺氧的分子反应以及在癌症治疗中的利用潜力。
The molecular response of mammalian cells to hypoxia and the potential for exploitation in cancer therapy.
作者信息
Dachs G U, Stratford I J
机构信息
Medical Research Council, Harwell, Didcot, UK.
出版信息
Br J Cancer Suppl. 1996 Jul;27:S126-32.
Abstract
In this review, reports of the increased expression of selected genes in response to hypoxia have been summarised. The best studied mammalian hypoxia response systems are those of the erythropoietin (Epo) and the vascular endothelial growth factor (VEGF) genes, which will be described in some detail. Other genes discussed here include those encoding growth factors, cytokines, transcription factors, metabolic enzymes and DNA repair enzymes. Short DNA sequences (hypoxia response elements) governing the increased gene expression in response to hypoxia have been discovered in the vicinity of most of these genes. The review will end by analysing the possibility of exploiting tumour hypoxia via the use of hypoxia response elements for gene therapy of cancer.
摘要
在本综述中，总结了关于特定基因在低氧反应中表达增加的报道。研究得最为透彻的哺乳动物低氧反应系统是促红细胞生成素（Epo）和血管内皮生长因子（VEGF）基因的反应系统，将对其进行较为详细的描述。这里讨论的其他基因包括编码生长因子、细胞因子、转录因子、代谢酶和DNA修复酶的基因。在这些基因中的大多数附近，已发现了调控基因在低氧反应中表达增加的短DNA序列（低氧反应元件）。本综述将通过分析利用低氧反应元件针对肿瘤低氧进行癌症基因治疗的可能性来结束。
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