Imoto T
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
EXS. 1996;75:163-81. doi: 10.1007/978-3-0348-9225-4_10.
As the most extensively investigated model protein, the protein engineering of lysozyme is described. By utilizing modifications made possible by chemical or gene engineering methods, we can get a better understanding of protein behaviour and we can also improve their properties. The results of the protein engineering of lysozyme are described, which give some ideas for a better understanding of the physiological function of proteins, their stabilization, and how to engineer a novel protein.
作为研究最为广泛的模型蛋白,本文描述了溶菌酶的蛋白质工程。通过利用化学或基因工程方法实现的修饰,我们可以更好地理解蛋白质的行为,还能改善其性质。文中描述了溶菌酶蛋白质工程的结果,这些结果为更好地理解蛋白质的生理功能、其稳定性以及如何设计新型蛋白质提供了一些思路。