3'-叠氮-3'-脱氧胸苷（AZT）对正常人多形核细胞及单核细胞-巨噬细胞功能的体外影响。
In vitro effects of 3'-azido-3'-deoxythymidine (AZT) on normal human polymorphonuclear cell and monocyte-macrophage functional capacities.
作者信息
De Simone C, Maffione A B, Calvello R, Nacci C, Sciannameo G, Greco B, Caradonna L, Pece S, Antonaci S, Jirillo E
机构信息
University of L'Aquila degli Abruzzi, Medical School, Italy.
出版信息
Immunopharmacol Immunotoxicol. 1996 May;18(2):161-78. doi: 10.3109/08923979609052730.
The in vitro effects of 3'-azido-3'-deoxythymidine (AZT) (at concentrations of 1, 10 and 100 microM, respectively) on normal human polymorphonuclear cell (PMN) and monocyte-macrophage functional capacities were evaluated. Results show that AZT was able to decrease monocyte phagocytosis only, while PMN polarization, phagocytosis and killing were unaffected by drug pretreatment. Quite interestingly, monocyte-derived macrophages maintained their unaltered phagocytic function in spite of the presence of AZT in overnight cultures, thus indicating that monocytes are more susceptible than macrophages to the antiproliferative effects of AZT. Since our data indicate that AZT affects normal human monocyte phagocytosis, it is advisable to evaluate this immune parameter in HIV+ patients administered with this drug.
评估了3'-叠氮-3'-脱氧胸苷（AZT）（分别以1、10和100微摩尔的浓度）对正常人多形核细胞（PMN）和单核细胞-巨噬细胞功能能力的体外作用。结果表明，AZT仅能降低单核细胞的吞噬作用，而药物预处理对PMN的极化、吞噬作用和杀伤作用没有影响。非常有趣的是，尽管过夜培养物中存在AZT，但单核细胞衍生的巨噬细胞仍保持其未改变的吞噬功能，因此表明单核细胞比巨噬细胞对AZT的抗增殖作用更敏感。由于我们的数据表明AZT会影响正常人单核细胞的吞噬作用，因此建议在接受该药物治疗的HIV+患者中评估这一免疫参数。
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