反复给予纳曲酮可加速吗啡依赖大鼠吗啡躯体戒断症状的消退。

Repeated naltrexone administration accelerates resolution of morphine somatic withdrawal signs in morphine-dependent rats.

作者信息

Muntoni A L, Diana M, Gessa G L

机构信息

B.B. Brodie Department of Neuroscience, University of Cagliari, Italy.

出版信息

Eur J Pharmacol. 1996 Apr 22;301(1-3):R9-10. doi: 10.1016/0014-2999(96)00126-4.

DOI:10.1016/0014-2999(96)00126-4

PMID:8773469

Abstract

Morphine-dependent rats were divided into two subgroups. The first was allowed to develop a spontaneous withdrawal syndrome which was still present 33 h after the last morphine administration. The second subgroup received five injections of naltrexone. While the first two injections of naltrexone precipitated a marked somatic withdrawal syndrome, subsequent naltrexone failed to worsen the somatic signs. 24 h after the last morphine administration, naltrexone was completely ineffective. It is concluded that naltrexone shortens the duration of the morphine somatic withdrawal signs in dependent rats.

摘要

吗啡依赖大鼠被分为两个亚组。第一组让其出现自发戒断综合征，在最后一次给予吗啡后33小时该综合征仍存在。第二亚组接受五次纳曲酮注射。虽然前两次纳曲酮注射引发了明显的躯体戒断综合征，但随后的纳曲酮未能使躯体症状恶化。在最后一次给予吗啡24小时后，纳曲酮完全无效。得出的结论是，纳曲酮可缩短依赖大鼠吗啡躯体戒断症状的持续时间。