用问号钩端螺旋体黄疸出血血清型的乙二胺四乙酸提取物对仓鼠进行实验性免疫接种。
Experimental immunization of hamsters with an EDTA extract of Leptospira interrogans, serovar icterohaemorrhagiae.
作者信息
de Queiroz-Leite L T, Resende M, Ramos-Vieira M das N, Cota-Koury M
机构信息
Departamento de Microbiologia, Universidade Federal de Minas Gerais, Brazil.
出版信息
Rev Latinoam Microbiol. 1996 Jan-Mar;38(1):39-43.
PMID:8783904
Abstract
The EDTA extract was prepared from the Leptospira interrogans serovar icterohaemorrhagiae. When inoculated subcutaneously in hamsters it conferred protection from challenge with virulent leptospires with a low dose (10 micrograms/ml) and low agglutinating antibody (40). The protection of animals obtained by the EDTA extract opens up the perspective of its use as a component of a vaccine for the control of leptospirosis.
摘要
乙二胺四乙酸（EDTA）提取物由黄疸出血型问号钩端螺旋体制备而成。当以低剂量（10微克/毫升）和低凝集抗体（40）皮下接种于仓鼠时，它能使仓鼠免受强毒钩端螺旋体攻击。通过EDTA提取物获得的动物保护作用为其作为控制钩端螺旋体病疫苗的一种成分的应用开辟了前景。
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