Cañas E, Pachon J, Garcia-Pesquera F, Castillo J R, Viciana P, Cisneros J M, Jimenez-Mejias M E
Infectious Diseases Unit, Hospital Universitario Virgen del Rocio, Seville, Spain.
Antimicrob Agents Chemother. 1996 Jan;40(1):230-3. doi: 10.1128/AAC.40.1.230.
Pharmacokinetic parameters of zidovudine (ZDV) were not altered in 16 patients receiving concomitant therapy with ZDV and trimethoprim-sulfamethoxazole by oral administration. ZDV areas under the concentration-time curves were (means +/- standard deviations) 1.80 +/- 0.70 and 1.69 +/- 0.64 micrograms.h/ml in the absence and presence of trimethoprim-sulfamethoxazole, respectively. ZDV clearances were 1.57 +/- 0.61 and 1.74 +/- 0.66 liters/h/kg, respectively.
16例接受齐多夫定(ZDV)与甲氧苄啶-磺胺甲恶唑口服联合治疗的患者,其齐多夫定的药代动力学参数未发生改变。在不存在和存在甲氧苄啶-磺胺甲恶唑的情况下,齐多夫定浓度-时间曲线下面积分别为(均值±标准差)1.80±0.70和1.69±0.64微克·小时/毫升。齐多夫定清除率分别为1.57±0.61和1.74±0.66升/小时/千克。