单胺排泄的个体内每日可靠性及个体间差异。

Day-to-day intraindividual reliability and interindividual differences in monoamines excretion.

作者信息

Curtin F, Walker J P, Schulz P

机构信息

Department of Psychiatry, Geneva University, IUPG, Switzerland.

出版信息

J Affect Disord. 1996 Jun 5;38(2-3):173-8. doi: 10.1016/0165-0327(96)00011-0.

DOI:10.1016/0165-0327(96)00011-0

PMID:8791186

Abstract

The urine of 44 normal men was collected during 2 nights to evaluate components of biological variation, i.e., intraindividual day-to-day variability and interindividual variability in monoamines excretion. Monoamines presented important interindividual variability [interindividual coefficients of variation (%): dopamine 18.3, norepinephrine 66.7, epinephrine 85.3, normetanephrine 22.4, metanephrine 76.8, 3-methoxy-4-hydroxyphenylglycol (MHPG) 77.0, vanilmandelic acid (VMA) 64.3, homovanilic acid (HVA) 71.3, 5-hydroxyindolacetic acid (5-HIAA) 20.4]. The reliability of these amounts was high, with intraclass correlation coefficients ranging from 0.43 (P < 0.001) for MHPG free form to 0.65 (P < 10(-6)) for dopamine and normetanephrine (intraindividual coefficients of variation (%): dopamine 8.5, norepinephrine 39.9, epinephrine 45.9, normetanephrine 10.3, metanephrine 46.3, MHPG 37.5, VMA 30.7, HVA 41.0, 5-HIAA 12.3).

摘要

收集了44名正常男性在两个晚上的尿液，以评估生物变异的组成部分，即单胺排泄的个体内每日变异性和个体间变异性。单胺呈现出重要的个体间变异性[个体间变异系数（%）：多巴胺18.3、去甲肾上腺素66.7、肾上腺素85.3、去甲变肾上腺素22.4、变肾上腺素76.8、3-甲氧基-4-羟基苯乙二醇（MHPG）77.0、香草扁桃酸（VMA）64.3、高香草酸（HVA）71.3、5-羟吲哚乙酸（5-HIAA）20.4]。这些量的可靠性很高，组内相关系数范围从游离形式的MHPG的0.43（P<0.001）到多巴胺和去甲变肾上腺素的0.65（P<10^(-6)）[个体内变异系数（%）：多巴胺8.5、去甲肾上腺素39.9、肾上腺素45.9、去甲变肾上腺素10.3、变肾上腺素46.3、MHPG 37.5、VMA 30.7、HVA 41.0、5-HIAA 12.3]。