Wang D
Department of Computer and Information Science, Ohio State University, Columbus, OH 43210, USA.
J Comput Neurosci. 1994 Dec;1(4):285-99. doi: 10.1007/BF00961877.
A critical problem in neurobiology is to explain how the central nervous system coordinates pattern discrimination and locus specificity in learning. This problem is investigated in anuran amphibians who demonstrate both locus specificity and pattern discrimination in visual habituation. A neural mechanism is proposed whereby neural circuitry for pattern discrimination is shared by a spatial memory system. Such learning processes are argued to occur in the medial pallium (MP), the anuran's homolog of mammalian hippocampus. Necessary mapping from the shared network to spatial memory is set up by a mechanism that forms topographical connections, with desired orientation determined by activity gradient in presynaptic and postsynaptic layers. The model of MP is tested on both locus and stimulus specific habituation, which involve short-term as well as long-term synaptic plasticity. Successful modeling yields a set of predictions concerning MP organization and learning properties.
神经生物学中的一个关键问题是解释中枢神经系统如何在学习过程中协调模式辨别和位置特异性。这个问题在无尾两栖动物中进行了研究，它们在视觉习惯化中表现出位置特异性和模式辨别能力。本文提出了一种神经机制，即模式辨别神经回路由空间记忆系统共享。这种学习过程被认为发生在内侧大脑皮层（MP），即无尾两栖动物中与哺乳动物海马体同源的结构。通过一种形成拓扑连接的机制建立从共享网络到空间记忆的必要映射，突触前层和突触后层的活动梯度决定了所需的方向。MP模型在位置和刺激特异性习惯化方面进行了测试，这涉及短期和长期的突触可塑性。成功的建模产生了一组关于MP组织和学习特性的预测。
