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[抗生素合成过程中左旋放线菌和霉肝糖链霉菌初始菌株及筛选菌株的脂质组成]

[Lipid makeup of the initial and selected strains of Actinomyces levoris and Streptoverticillium mycoheptinicum in the process of antibiotic synthesis].

作者信息

Efimova T P, Zhukova R A, Starshinova E N, Kudriashova N G

出版信息

Antibiotiki. 1977 May;22(5):400-4.

PMID:879723
Abstract

The study of the lipid composition showed that the rate of the changes in the fatty acid composition of neutral lipids and phospholipids in the selected strains was higher than that in the initial strains. The medium composition had the decisive effect on the fractional and fatty acid spectrum of the mycelium lipids. When the antibiotic-producing organisms were grown on the synthetic medium the phospholipids were the predominating fractions (70--90 per cent of the total lipids), while with the use of organic medium they amounted only to 30--40 per cent. The data were evident of complex correlation between the synthesis of fatty acids and polyenic antibiotics, i.e. levorin and mycoheptin.

摘要

脂质成分的研究表明,所选菌株中中性脂质和磷脂的脂肪酸组成变化速率高于初始菌株。培养基成分对菌丝体脂质的组分和脂肪酸谱具有决定性作用。当抗生素产生菌在合成培养基上生长时,磷脂是主要组分(占总脂质的70 - 90%),而使用有机培养基时,它们仅占30 - 40%。这些数据表明脂肪酸和多烯抗生素(即左菌素和霉菌烯素)的合成之间存在复杂的相关性。

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