绑定复制起点的两个步骤？DNA与蛋白质的相互作用。

Two steps to binding replication origins? DNA-protein interactions.

作者信息

Dean F B, O'Donnell M

机构信息

Microbiology Department, Hearst Research Foundation and Howard Hughes Medical Institute, Cornell University Medical College, 1300 York Avenue, New York, New York 10021, USA.

出版信息

Curr Biol. 1996 Aug 1;6(8):931-4. doi: 10.1016/s0960-9822(02)00629-2.

DOI:10.1016/s0960-9822(02)00629-2

PMID:8805327

Abstract

Recent structural studies of the Epstein-Barr virus EBNA1 protein bound to DNA suggest that it binds to DNA replication origins in a two-step process; the first step involves recognition of the correct sequence and the second initiates structural changes in the DNA.

摘要

近期对与DNA结合的爱泼斯坦-巴尔病毒EBNA1蛋白的结构研究表明，它通过两步过程与DNA复制起点结合；第一步涉及识别正确序列，第二步引发DNA的结构变化。