Matsukuma S, Aida S, Hata Y, Sugiura Y, Tamai S
Department of Laboratory Medicine, National Defence Medical College, Tokorozawa, Japan.
Pathol Int. 1996 May;46(5):389-91. doi: 10.1111/j.1440-1827.1996.tb03627.x.
A case is presented of localized malignant peritoneal mesothelioma appearing as a liver neoplasm. The patient underwent tumor resection but developed a recurrent growth and died 10 months after the initial surgery. The primary tumor showed sarcomatous features with rhabdoid cells. Examination revealed the presence of hyaluronic acid, co-immunoreactivity for cytokeratin epithelial membrane antigen and vimentin, cellular contacts with small desmosomes, and intracytoplasmic lumina. These findings supported the mesothelial nature of this tumor. The recurrent tumor was composed of predominantly tubulopapillary proliferation. It was concluded that the present tumor was a localized malignant mesothelioma of a biphasic type showing a predominantly sarcomatous component in the primary tumor.
本文报告一例表现为肝脏肿瘤的局限性恶性腹膜间皮瘤。患者接受了肿瘤切除术，但出现复发并在初次手术后10个月死亡。原发性肿瘤表现出具有横纹肌样细胞的肉瘤特征。检查发现存在透明质酸，细胞角蛋白、上皮膜抗原和波形蛋白的共免疫反应性，带有小桥粒的细胞接触以及胞质内管腔。这些发现支持了该肿瘤的间皮性质。复发性肿瘤主要由管状乳头样增生组成。结论是，本肿瘤为双相型局限性恶性间皮瘤，原发性肿瘤中主要为肉瘤成分。
