Shah R M
Teratology. 1977 Jun;15(3):261-72. doi: 10.1002/tera.1420150308.
A 32-mm CRL male human embryo was examined for malformation. Histological observation showed fusion between the left vertical palatal shelf and mandible and the maxilla and mandible in the posterior part of the oronasal cavity. The right shelf was horizontal anteriorly, vertical posteriorly and changing its position from a vertical to a horizontal plane in the middle. The tongue was underdeveloped anteriorly and completely absent posteriorly. The mandibular tooth buds were not formed. Both clinical and experimental literature were analyzed to find the mechanism of statu nascendi defect observed in the present case. It was deduced that the tongue may not play an active role during normal palatal development and that it may not have played any role during the fusion between different intraoral structures observed in the present case. It was concluded that, had the embryo developed further, then at the birth a cleft palate, partial aglossia and associated intraoral malformation would have been expected.
对一个头臀长32毫米的男性人类胚胎进行了畸形检查。组织学观察显示，在口鼻腔后部，左侧垂直腭板与下颌骨以及上颌骨与下颌骨之间发生了融合。右侧腭板前部呈水平状，后部呈垂直状，且在中部从垂直平面转变为水平平面。舌头前部发育不全，后部完全缺失。下颌牙胚未形成。对临床和实验文献进行了分析，以找出本病例中所观察到的先天性缺陷的机制。据推断，舌头在正常腭部发育过程中可能未发挥积极作用，并且在本病例中所观察到的不同口腔内结构之间的融合过程中可能也未发挥任何作用。得出的结论是，如果胚胎进一步发育，那么出生时预计会出现腭裂、部分无舌症及相关的口腔内畸形。
