神经元型银环蛇毒素在胚胎发育过程中会取代神经肌肉接头处以及脊髓处的（125I）α-银环蛇毒素结合位点。
Neuronal bungarotoxin displaces (125I) alpha-bungarotoxin binding at the neuromuscular junction as well as to the spinal cord during embryogenesis.
作者信息
Renshaw G M, Goldie R
机构信息
Department of Anatomical Sciences, University of Queensland, St. Lucia, Australia.
出版信息
Brain Res. 1996 Feb 19;709(2):316-8. doi: 10.1016/0006-8993(95)01388-1.
PMID:8833769
Abstract
Alpha-Bungarotoxin (alpha BTX) administration in ovo prevents motoneuron apoptosis during development. This process may be mediated by alpha BTX-sensitive nicotinic cholinoceptors in the spinal cord, at the neuromuscular junction or at both sites. In order to differentiate between these possibilities, neuronal bungarotoxin binding (NBTX) binding to embryonic muscle and spinal cord was investigated in the chick.
摘要
在鸡胚中注射α-银环蛇毒素（α-BTX）可防止运动神经元在发育过程中发生凋亡。这一过程可能由脊髓中、神经肌肉接头处或这两个部位对α-BTX敏感的烟碱型胆碱受体介导。为了区分这些可能性，研究了鸡胚中神经元型银环蛇毒素结合（NBTX）与胚胎肌肉和脊髓的结合情况。
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