一株淋病奈瑟菌临床分离株，对红霉素具有体外耐药性，对阿奇霉素的敏感性降低。

A clinical isolate of Neisseria gonorrhoeae with in vitro resistance to erythromycin and decreased susceptibility to azithromycin.

作者信息

Ehret J M, Nims L J, Judson F N

机构信息

Denver Public Health Department, University of Colorado Health Sciences Center, USA.

出版信息

Sex Transm Dis. 1996 Jul-Aug;23(4):270-2. doi: 10.1097/00007435-199607000-00004.

DOI:10.1097/00007435-199607000-00004

PMID:8836018

Abstract

BACKGROUND AND OBJECTIVES

Erythromycin is a recommended treatment for penicillin-allergic pregnant women with gonorrhea, and azithromycin has been suggested as therapy for coexisting gonococcal and chlamydial infections. Although gonococcal resistance to erythromycin is not uncommon, decreased resistance to azithromycin is rare. A clinical isolate of Neisseria gonorrhoeae with in vitro resistance to erythromycin and decreased susceptibility to azithromycin is reported.

STUDY DESIGN

This is a case report.

RESULTS

Antimicrobial susceptibility testing of a clinical isolate of N. gonorrhoeae revealed a minimal inhibitory concentration (MIC) of 2 micrograms/ml to azithromycin and 32 micrograms/ml to erythromycin. Five hundred other urethral isolates were tested, resulting in an MIC for erythromycin ranging from 0.015 to 2 micrograms/ml. The range for azithromycin was 0.015 to 0.5 micrograms/ml. There was a strong correlation between erythromycin and azithromycin MICs (r = 0.73; P < 0.0001).

CONCLUSIONS

Continued national monitoring is needed to detect the appearance and early dissemination of new types of gonococcal resistance.

摘要

背景与目的

红霉素是推荐用于对青霉素过敏的淋病孕妇的治疗药物，阿奇霉素已被建议用于治疗合并存在的淋球菌和衣原体感染。尽管淋球菌对红霉素耐药并不罕见，但对阿奇霉素耐药性降低的情况却很少见。本文报告了一株对红霉素体外耐药且对阿奇霉素敏感性降低的淋病奈瑟菌临床分离株。

研究设计

这是一篇病例报告。

结果

一株淋病奈瑟菌临床分离株的药敏试验显示，其对阿奇霉素的最低抑菌浓度（MIC）为2微克/毫升，对红霉素的MIC为32微克/毫升。对另外500株尿道分离株进行了检测，红霉素的MIC范围为0.015至2微克/毫升。阿奇霉素的范围为0.015至0.5微克/毫升。红霉素和阿奇霉素的MIC之间存在很强的相关性（r = 0.73；P < 0.0001）。