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1980年至1990年间进行的高选择性迷走神经切断术的长期临床结果。

Long-term clinical results of highly selective vagotomy performed between 1980 and 1990.

作者信息

Ihász M, Bátorfi J, Bálint A, Fazekas T, Máté M, Pòsfai G, Sándor J

机构信息

Third Department of Surgery, Semmelweis Medical University, Budapest, Hungary.

出版信息

Surg Today. 1996;26(7):546-51. doi: 10.1007/BF00311565.

DOI:10.1007/BF00311565
PMID:8840440
Abstract

A retrospective analysis was conducted of 778 patients who underwent highly selective vagotomy between 1980 and 1990. Surgery was performed for duodenal ulcers without any complications in 485 (62.3%) patients; for duodenal ulcers with complications such as stenosis, bleeding, or perforation in 270 (34.7%); for combined duodenal and ventricular ulcers in 12 (1.5%), and for ventricular ulcers alone in 11 (1.4%). Pyloroplasty was additionally performed in the presence of complications only. The incidence of intraoperative complications proved to be as high as 1.4%, occurring in 11 patients, while postoperative complications developed in 247 patients (31.7%). Although the overall mortality was 0.6% (5 patients), the mortality rate of those patients who underwent surgery for uncomplicated ulcer disease was 0.2% only (2 patients). The patients comprised 554 men (71.2%) and 224 women (28.8%) with an average age of 41.4 +/- 0.7 years. The average duration of duodenal ulcer disease was 9.5 years, and 643 (83.2%) of the patients were able to be regularly followed up for between 3 and 13 years. Recurrence developed in 62 patients (9.6%): in the duodenum in 57 patients (91.9%), and in the stomach in 5 (8.1%). The rate of recurrence according to sex was 9.4% in men and 10.3% in women, being 42 and 20 patients, respectively. The average duration until recurrence appeared was 27.06 +/- 3.44 months. A reoperation proved necessary in 28 of these 62 patients (45.1%). The clinical results were evaluated by means of a modified Visick classification, according to which 81.8% of the patients belonged to groups 1 or 2, 7.9% to group 3, and 10.3% to group 4.

摘要

对1980年至1990年间接受高选择性迷走神经切断术的778例患者进行了回顾性分析。485例(62.3%)患者因无任何并发症的十二指肠溃疡接受手术;270例(34.7%)因十二指肠溃疡伴有狭窄、出血或穿孔等并发症接受手术;12例(1.5%)因十二指肠溃疡合并胃溃疡接受手术,11例(1.4%)仅因胃溃疡接受手术。仅在出现并发症时才额外进行幽门成形术。术中并发症发生率高达1.4%,11例患者出现并发症,而术后并发症发生在247例患者中(31.7%)。尽管总死亡率为0.6%(5例患者),但因无并发症溃疡病接受手术的患者死亡率仅为0.2%(2例患者)。患者包括554名男性(71.2%)和224名女性(28.8%),平均年龄为41.4±0.7岁。十二指肠溃疡病的平均病程为9.5年,643例(83.2%)患者能够接受3至13年的定期随访。62例患者(9.6%)复发:57例(91.9%)在十二指肠复发,5例(8.1%)在胃复发。按性别计算的复发率男性为9.4%,女性为10.3%,分别为42例和20例。复发出现的平均时间为27.06±3.44个月。这62例患者中有28例(45.1%)需要再次手术。临床结果采用改良的Visick分类法进行评估,据此81.8%的患者属于1组或2组,7.9%属于3组,10.3%属于4组。

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本文引用的文献

1
Experimental basis and clinical application of extended highly selective vagotomy for duodenal ulcer.十二指肠溃疡扩大高选择性迷走神经切断术的实验基础与临床应用
Surg Gynecol Obstet. 1993 Jan;176(1):39-48.
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Six-year results of a prospective, randomized trial of selective proximal vagotomy with and without pyloroplasty in the treatment of duodenal, pyloric, and prepyloric ulcers.一项关于在十二指肠溃疡、幽门溃疡和幽门前溃疡治疗中采用选择性近端迷走神经切断术联合或不联合幽门成形术的前瞻性随机试验的六年结果。
Ann Surg. 1993 Jan;217(1):6-14. doi: 10.1097/00000658-199301000-00003.
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Hepatogastroenterology. 1993 Jun;40(3):267-71.
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Proximal gastric vagotomy interferes with a fundic inhibitory mechanism. A hypothesis for the high recurrence rate of peptic ulceration.近端胃迷走神经切断术干扰了胃底抑制机制。这是消化性溃疡高复发率的一种假说。
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