Norman J C, Cooley D A, Hallman G L, Nihill M R
Circulation. 1977 Sep;56(3 Suppl):II62-5.
Cardiologists and surgeons are occasionally faced with therapeutic dilemmas regarding the management of recurrent left ventricular outflow tract obstructions, such as supravalvular, valvular, subvalvular or "tunnel" stenoses and obstructive myopathies. Following an extended series of biomaterial, hemodynamic, reliability and configuration studies in calves, we have created double-outlet left ventricles in 11 patients. All gradients were markedly reduced. All patients were discharged without anticoagulants, and the longest follow-up period is in excess of 1 year. In eight cases, the percent of cardiac output flowing antegrade and retrograde was quantitated with velocity-tipped catheters. An average ratio of 2:1 (antegrade [ascending aorta]: retrograde [composite conduit]) was found. The procedure is simple and effective in relieving primary or recurrent left ventricular outflow tract obstructions.
心脏病专家和外科医生在处理复发性左心室流出道梗阻(如瓣上、瓣膜、瓣下或“隧道”狭窄以及梗阻性肌病)时,偶尔会面临治疗难题。在对小牛进行了一系列广泛的生物材料、血流动力学、可靠性和结构研究之后,我们为11例患者构建了双出口左心室。所有压力阶差均显著降低。所有患者出院时均未使用抗凝剂,最长随访期超过1年。在8例患者中,使用带流速探头的导管对向前和向后流动的心输出量百分比进行了定量分析。发现平均比例为2:1(向前[升主动脉]:向后[复合管道])。该手术在缓解原发性或复发性左心室流出道梗阻方面简单有效。