Mutani R, Agnetti V, Durelli L, Fassio F, Ganga A
J Neurol. 1979 May 2;220(3):215-22. doi: 10.1007/BF00705539.
A woman, aged 30, experienced attacks of pathological laughter which began during the first months of life; they meet the qualifying criteria of epileptic laughter. Several attacks were recorded by polygraphy and cinefilm. The attack begins with a feeling of unreality associated with a forced, involuntary smile progressing to full laughter. The patient tried to mask the laughter which was not accompanied by euphoria but was followed by loss of consciousness and automatisms. Only during the latter phase of the previously normal EEG did an ictal discharge appear over the right hemisphere. On the basis of the electroclinical pattern and of a review of the literature, the seizure is tentatively explained in terms of a progressive ictal involvement of temporodiencephalic structures.
一名30岁女性自出生后最初几个月起便出现病理性大笑发作；这些发作符合癫痫性大笑的诊断标准。通过多导生理记录仪和电影摄影记录了几次发作情况。发作始于一种与强迫性、不自主微笑相关的现实感缺失，随后发展为放声大笑。患者试图掩饰这种大笑，这种大笑并非伴有欣快感，而是继以意识丧失和自动症。仅在先前正常脑电图的后期阶段，右半球才出现发作期放电。根据电临床模式及文献回顾，该发作初步被解释为颞间脑结构的进行性发作期受累。
