Carlson C S, Loeser R F, Purser C B, Gardin J F, Jerome C P
Department of Comparative Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina, USA.
J Bone Miner Res. 1996 Sep;11(9):1209-17. doi: 10.1002/jbmr.5650110904.
Knee joints from cynomolgus monkeys of both genders and a wide range of ages were examined to characterize further the natural history of osteoarthritis (OA) in these animals. The objectives of this study were to characterize better the subchondral bone changes previously noted in this disease, to determine whether the severity of OA in these animals is affected by age or weight, and to determine whether males and females are affected similarly. As had been seen in previous studies, the medial tibial plateau was the most severely affected site. The thickness of the subchondral plate in the medial tibial plateau increased with increasing severity of articular cartilage lesions in both males and females; however, in monkeys with subchondral plate thicknesses less than 400 microns, articular cartilage lesions were essentially absent. Subchondral plate thickness increased with increasing weight in both genders, but females had a higher subchondral plate thickness than males for a given body weight. There was no correlation between bone volume in the proximal tibial epiphysis and articular cartilage lesions of OA. The prevalence and severity of OA in the medial tibial plateau increased with increasing age, but were not affected by gender or weight. Although there was no correlation between articular cartilage lesions and body mass index or weight, the waist/hip circumference ratio and severity of articular cartilage lesions were correlated in the female monkeys. This work provides evidence that thickening of the subchondral bone plate may be more important than the volume of epiphyseal/metaphyseal cancellous bone in determining the biomechanical stresses in the joint and in influencing the development of articular cartilage lesions.
对不同性别和年龄范围的食蟹猴膝关节进行检查，以进一步描述这些动物骨关节炎（OA）的自然病史。本研究的目的是更好地描述该疾病中先前观察到的软骨下骨变化，确定这些动物OA的严重程度是否受年龄或体重影响，以及确定雄性和雌性受影响的情况是否相似。如先前研究中所见，内侧胫骨平台是受影响最严重的部位。在雄性和雌性中，内侧胫骨平台软骨下板的厚度随关节软骨损伤严重程度的增加而增加；然而，在软骨下板厚度小于400微米的猴子中，基本上没有关节软骨损伤。软骨下板厚度在两性中均随体重增加而增加，但在给定体重下，雌性的软骨下板厚度高于雄性。胫骨近端骨骺的骨体积与OA的关节软骨损伤之间没有相关性。内侧胫骨平台OA的患病率和严重程度随年龄增加而增加，但不受性别或体重影响。虽然关节软骨损伤与体重指数或体重之间没有相关性，但在雌性猴子中，腰臀围比与关节软骨损伤的严重程度相关。这项工作提供了证据，表明在确定关节的生物力学应力和影响关节软骨损伤的发展方面，软骨下骨板增厚可能比骨骺/干骺端松质骨体积更重要。
