7-羟基-DPAT对大鼠产生的条件性味觉厌恶的特征

Characterization of the conditioned taste aversion produced by 7-OH-DPAT in rats.

作者信息

Bevins R A, Delzer T A, Bardo M T

机构信息

Department of Psychology, University of Kentucky, Lexington 40506-0044, USA.

出版信息

Pharmacol Biochem Behav. 1996 Mar;53(3):695-9. doi: 10.1016/0091-3057(95)02071-3.

DOI:10.1016/0091-3057(95)02071-3

PMID:8866974

Abstract

Using the conditioned taste aversion preparation, we described the dose-effect curve for the reputed dopamine D3 agonist (+/-)7-OH-DPAT (0, 0.001, 0.01, 0.1, 1.0, or 10 mg/kg). Rats received a 0.1% saccharin taste paired on repeated occasions with one of the 7-OH-DPAT doses. The 0.1, 1.0, and 10.0 mg/kg doses of 7-OH-DPAT produced a significant conditioned saccharin aversion. This aversion was evident regardless of whether saccharin intake of 7-OH-DPAT-treated rats was compared to their own water consumption or to saccharin intake by saline-treated rats.

摘要

使用条件性味觉厌恶实验，我们描绘了公认的多巴胺D3激动剂（±）7-羟基-DPAT（0、0.001、0.01、0.1、1.0或10 mg/kg）的剂量效应曲线。大鼠多次接受0.1%糖精味与7-羟基-DPAT的其中一个剂量配对。7-羟基-DPAT的0.1、1.0和10.0 mg/kg剂量产生了显著的条件性糖精厌恶。无论将7-羟基-DPAT处理组大鼠的糖精摄入量与其自身的饮水量相比，还是与盐水处理组大鼠的糖精摄入量相比，这种厌恶都是明显的。