Meyer H J, Jähne J, Hiller W F, Tusch G, Stukenborg C, Pichlmayr R
Klinik für Abdominal- und Transplantationschirurgie, Zentrum Chirurgie der Medizinischen Hochschule Hannover.
Zentralbl Chir. 1996;121(2):106-9.
Surgical procedures including the extent of systematic lymphadenectomy are still under discussion in the treatment of esophageal cancer. In the own patients' population 92 subtotal en bloc-esophagectomies with a standard two field lymphadenectomy were performed. A total of 1483 lymph nodes were resected in the thoracic and abdominal compartments with an incidence of 16.1% being metastatic. Stage pN1 disease occurred in 57.6% of the patients. The median number of lymph nodes resected in each specimen was 16, independent of tumor stage, -site or R-classification. The number of infiltrated nodes increased with tumor stages. R-classification, tumor stage and number of involved lymph nodes could be analyzed as prognostic factors. After R0-resection a median survival rate of 25.4 months could be achieved, following pN0-stage that of 27.4 months. In case of two metastatic lymph nodes the prognosis decreased significantly to 14.4 months (p < 0.01). Therefore, two field lymphadenectomy may show a therapeutic benefit only in a subgroup of patients with a limited number of lymph nodes infiltrated.
包括系统性淋巴结清扫范围在内的外科手术方法在食管癌治疗中仍存在争议。在我们自己的患者群体中,进行了92例标准两野淋巴结清扫的次全整块食管切除术。在胸段和腹段共切除1483个淋巴结,其中16.1%发生转移。57.6%的患者出现pN1期疾病。每个标本切除的淋巴结中位数为16个,与肿瘤分期、部位或R分级无关。受累淋巴结数量随肿瘤分期增加。R分级、肿瘤分期和受累淋巴结数量可作为预后因素进行分析。R0切除后,中位生存率可达25.4个月,pN0期为27.4个月。若有两个转移淋巴结,预后显著下降至14.4个月(p<0.01)。因此,两野淋巴结清扫可能仅在受累淋巴结数量有限的亚组患者中显示出治疗益处。