Bolden D A
Istituto di Anatomia ed Istologia, Facoltà di Medicina e Chirurgia, Verona, Italy.
Neurosci Lett. 1996 Aug 23;214(2-3):83-6. doi: 10.1016/0304-3940(96)12891-3.
The induction of the immediate early gene product c-Jun was investigated in trigeminal ganglia following surgical removal of the superior cervical ganglion (SCG). A 5-fold increase in c-Jun-immunoreactive neurons was detected by 48 h post-surgery in ipsilateral trigeminal ganglia of sympathectomized rats. This increase persisted for 6 days. When examined 4 months after sympathectomy, c-Jun expression had returned to basal levels. The possibility that trigeminal neurons project to the SCG, and therefore induce c-Jun by being axotomized by sympathectomy, was also examined using retrograde fluorescent tracing. A very limited number of trigeminal neurons were retrogradely labeled from the SCG. These data indicate that c-Jun induction occurs in sensory neurons following perturbations to sympathetic ganglia, and that trigeminal neurons may project to the SCG, but that c-Jun induction cannot be ascribed to axotomy following surgical sympathectomy. Thus, these findings support anatomical and functional interconnections between the sensory and autonomic nervous systems. The relationship of c-Jun induction with plasticity phenomena is discussed.
在切除颈上神经节（SCG）后，研究了三叉神经节中即刻早期基因产物c-Jun的诱导情况。在交感神经切除大鼠的同侧三叉神经节中，术后48小时检测到c-Jun免疫反应性神经元增加了5倍。这种增加持续了6天。在交感神经切除4个月后检查时，c-Jun表达已恢复到基础水平。还使用逆行荧光追踪法研究了三叉神经元投射到SCG并因此因交感神经切除而被轴突切断从而诱导c-Jun的可能性。从SCG逆行标记的三叉神经元数量非常有限。这些数据表明，在交感神经节受到扰动后，感觉神经元中会发生c-Jun诱导，并且三叉神经元可能投射到SCG，但c-Jun诱导不能归因于手术交感神经切除后的轴突切断。因此，这些发现支持了感觉神经系统和自主神经系统之间的解剖学和功能联系。讨论了c-Jun诱导与可塑性现象的关系。
