高效毛细管电泳法与液相色谱法测定药物及尿液中阿昔洛韦和鸟嘌呤的比较
Comparison of high performance capillary electrophoresis and liquid chromatography for the determination of acyclovir and guanine in pharmaceuticals and urine.
作者信息
Zhang S S, Liu H X, Chen Y, Yuan Z B
机构信息
Center of Instrumental Analysis, Zhengzhou University, P.R. China.
出版信息
Biomed Chromatogr. 1996 Sep-Oct;10(5):256-7. doi: 10.1002/(SICI)1099-0801(199609)10:5<256::AID-BMC600>3.0.CO;2-C.
High-performance capillary electrophoresis (HPCE) and high-performance liquid chromatography (HPLC) were developed and applied to the determination of acyclovir (ACV) and guanine (G) in pharmaceuticals. The comparison study showed that two methods gave comparable results in linear range, recovery and reproducibility. HPCE was used for the determination of ACV and G in urine; the recovery was better than 81.3% and the RSD was less than 4.4%.
高效毛细管电泳（HPCE）和高效液相色谱（HPLC）被开发并应用于药物中阿昔洛韦（ACV）和鸟嘌呤（G）的测定。对比研究表明，两种方法在线性范围、回收率和重现性方面给出了可比的结果。HPCE用于尿液中ACV和G的测定；回收率优于81.3%，相对标准偏差小于4.4%。
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