Kawakami H, Mikawa M, Takagi J, Nagaoka S
Department of Industrial Chemistry, Tokyo Metropolitan University, Japan.
J Biomater Sci Polym Ed. 1996;7(12):1029-38. doi: 10.1163/156856296x00525.
Fluorinated polyimide derived from 2,2'-bis(3,4-dicarboxyphenyl) hexafluoropropane dianhydride (6FDA) and bis[4-(4-aminophenoxy) phenyl]sulfone (APPS) was synthesized to develop a novel membrane oxygenator combining excellent gas transfer and blood compatibility. The asymmetric gas exchange membranes of 6FDA-APPS made by a dry/wet process consisted of an ultrathin and defect-free skin layer supported by a porous substructure. O2 transfer through the 6FDA-APPS membrane was extremely augmented as compared with that of the presently available membrane, poly(dimethylsiloxane), and the previously reported 6FDA-DDS membrane. Since CO2 transfer through the 6FDA-APPS membrane increased with a decrease in CO2 pressure according to dual-mode transport theory, CO2 from the membrane was selectively removed at low CO2 pressure. For the evaluation of in vitro blood compatibility, the platelet adhesion and the plasma protein adsorption on the surface of the 6FDA-APPS membrane were observed by using scanning electron microscopy and the amounts of platelet and plasma protein were determined by an amino acid analyzer. The results indicated that the fluorinated polyimide membranes showed excellent blood compatibility.
由2,2'-双(3,4-二羧基苯基)六氟丙烷二酐(6FDA)和双[4-(4-氨基苯氧基)苯基]砜(APPS)衍生的氟化聚酰亚胺被合成出来，以开发一种结合了优异气体传输性能和血液相容性的新型膜式氧合器。通过干/湿工艺制备的6FDA-APPS不对称气体交换膜由一个由多孔亚结构支撑的超薄且无缺陷的皮层组成。与目前可用的膜聚二甲基硅氧烷以及先前报道的6FDA-DDS膜相比，通过6FDA-APPS膜的氧气传输极大地增强了。根据双模传输理论，由于通过6FDA-APPS膜的二氧化碳传输随着二氧化碳压力的降低而增加，因此在低二氧化碳压力下，膜中的二氧化碳被选择性地去除。为了评估体外血液相容性，通过扫描电子显微镜观察6FDA-APPS膜表面的血小板粘附和血浆蛋白吸附情况，并通过氨基酸分析仪测定血小板和血浆蛋白的量。结果表明，氟化聚酰亚胺膜表现出优异的血液相容性。
