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寄生虫侵袭中的免疫反应(作者译)

[Immunologic reaction in parasitic invasion (author's transl)].

作者信息

Zwisler O

出版信息

Z Parasitenkd. 1977 Jun 3;52(1):1-10. doi: 10.1007/BF00380552.

Abstract

Among the manifold immunologic events which take place during parasitic invasions, production of autoantibodies and immune complexes can play a serious role during infections with African and American trypanosomes. The importance of complement deserves new attention. The increasing level of IgE induced by helminthic infections on a humoral basis seems to be caused by separate worm allergens; its involvement in self-cure phenomena together with processes on cellular levels is discussed. Destructive processes on various development stages of schistosoma and immunological events during cutaneous leishmaniasis are also cell mediated. Variations in the antigenic behaviour of parasites and their immunological mimicry by uptake of substances from the host and their immunosuppressive action are discussed. As reasons for absence of immunity against animal parasites this action can disturb either humoral or cellular immunological procedures or both.

摘要

在寄生虫入侵过程中发生的众多免疫事件中,自身抗体和免疫复合物的产生在非洲和美洲锥虫感染期间可能起重要作用。补体的重要性值得重新关注。蠕虫感染在体液基础上诱导的IgE水平升高似乎是由不同的蠕虫过敏原引起的;本文讨论了其在自愈现象中的作用以及与细胞水平过程的关系。血吸虫不同发育阶段的破坏过程以及皮肤利什曼病期间的免疫事件也是细胞介导的。本文还讨论了寄生虫抗原行为的变化、它们通过摄取宿主物质进行的免疫模拟及其免疫抑制作用。作为对动物寄生虫缺乏免疫力的原因,这种作用可能会干扰体液或细胞免疫程序,或两者皆有。

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