草酸钙肾结石形成的危险因素及其与草酸钙尿液过饱和度的关系。
Risk factors in urinary calcium oxalate stone formation and their relation to urinary calcium oxalate supersaturation.
作者信息
Ogawa Y, Hatano T
机构信息
Department of Urology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
出版信息
Int J Urol. 1996 Sep;3(5):356-60. doi: 10.1111/j.1442-2042.1996.tb00553.x.
BACKGROUND
We studied the effect of potential risk factors of urinary calcium oxalate saturation on calcium oxalate stone formation.
METHODS
Using the Equil2 program, the DG values of calcium oxalate in 390 clinical urine specimens were estimated in 5 healthy male individuals with and without citrate therapy.
RESULTS
Critical calcium-oxalate supersaturation (DG value, > 2.8) was noted in 15 out of 390 urine specimens. Of the 15, 14 late night or morning specimens had critical calcium oxalate supersaturation, while only 1 afternoon specimen was supersaturated. Critical calcium oxalate supersaturation was often associated with hyperoxaluria and hypercalciuria, while undersaturation was often associated with hypomagnesiuria, a high Ca/Mg ratio, and hypocitraturia.
CONCLUSIONS
Hypomagnesiuria, hypocitraturia, and a high Ca/Mg ratio appear to be poor indicators of calcium-oxalate supersaturation, and it is hard to predict the level of calcium-oxalate saturation using single parameters.
背景
我们研究了草酸钙尿饱和度潜在风险因素对草酸钙结石形成的影响。
方法
使用Equil2程序，在5名接受和未接受柠檬酸盐治疗的健康男性个体中，估计390份临床尿液标本中草酸钙的DG值。
结果
390份尿液标本中有15份出现临界草酸钙过饱和（DG值，> 2.8）。在这15份标本中，14份深夜或清晨标本出现临界草酸钙过饱和，而只有1份下午标本过饱和。临界草酸钙过饱和常与高草酸尿症和高钙尿症相关，而过低饱和常与低镁尿症、高钙镁比和低枸橼酸尿症相关。
结论
低镁尿症、低枸橼酸尿症和高钙镁比似乎不是草酸钙过饱和的良好指标，很难使用单一参数预测草酸钙饱和度水平。
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