Pesonen E, Kaprio J, Martimo P, Ruismäki A
Children's Hospital, Department of Pediatrics, University of Helsinki, Finland.
Coron Artery Dis. 1996 Jun;7(6):459-65. doi: 10.1097/00019501-199606000-00009.
Newborn children already have marked intimal thickenings in their coronary arteries. The magnitude of such thickenings increases with age and is associated with the coronary artery disease mortality of the grandparents. Topographies of such thickenings were investigated.
Cross-sections of the coronary arteries of 71 autopsied children were studied morphometrically at 200 microns intervals. A three-dimensional model was constructed from 16 serial sections by digitizing both the inner and the outer borders of the serial sections. A B-spline surface was constructed.
The arterial media was thinner under large intimal thickening. In a three-dimensional model the luminal surface could be seen through the outer surface. Intimal thickening narrowed the coronary lumen. In a sagittal longitudinal cross-section along the course of the coronary artery, a hypothetical coronary "angiocardiogram' demonstrated a narrowing in the proximal coronary artery.
Intimal thickenings that narrow the coronary artery lumen appear in the beginning of the left coronary artery in children, as does atherosclerosis in adults.
新生儿的冠状动脉已经出现明显的内膜增厚。这种增厚的程度随年龄增长而增加，并且与祖父母的冠状动脉疾病死亡率相关。对这种增厚的部位进行了研究。
对71例尸检儿童的冠状动脉横断面进行形态计量学研究，间隔200微米。通过对连续切片的内边界和外边界进行数字化处理，从16个连续切片构建三维模型。构建了B样条曲面。
在大的内膜增厚下方，动脉中膜较薄。在三维模型中，可以透过外表面看到管腔表面。内膜增厚使冠状动脉管腔变窄。在沿冠状动脉走行的矢状纵切面上，一个假想的冠状动脉“血管造影”显示冠状动脉近端变窄。
使冠状动脉管腔变窄的内膜增厚出现在儿童左冠状动脉起始处，与成人动脉粥样硬化的情况相同。
