Bäder M, Koppenhagen K
Department of Radiology and Nuclear Medicine, University Medical Center Benjamin Franklin, Free University of Berlin, Germany.
Recent Results Cancer Res. 1996;142:137-62. doi: 10.1007/978-3-642-80035-1_10.
Somatostatin receptor scintigraphy is a new, very sensitive procedure for detecting receptor-positive neuroendocrine tumors. Radiolabeled somatostatin analogues are selectively taken up after intravenous administration by tissue carrying somatostatin receptors and, as with the skeletal scintiscan, permit a whole-body visualization of receptor-positive tumors and metastases. Somatostatin receptor scintigraphy shows an overall sensitivity of about 84% for neuroendocrine gastroenteropancreatic tumors. This kind of scintigraphy should be applied in primary tumor localization, staging, and course control in a confirmed or highly probable neuroendocrine gastroenteropancreatic tumor. Furthermore, the use of a gamma probe for intraoperative tumor localization is demonstrated. Therapy with radioactively marked somatostatin analogues should be possible because of the highly selective tumor uptake. The development of an optimal tracer is the subject of current research.
生长抑素受体闪烁扫描术是一种用于检测受体阳性神经内分泌肿瘤的新型、高灵敏度检查方法。静脉注射后，放射性标记的生长抑素类似物会被携带生长抑素受体的组织选择性摄取，与骨闪烁扫描一样，可实现受体阳性肿瘤和转移灶的全身显像。生长抑素受体闪烁扫描术对神经内分泌胃肠胰肿瘤的总体灵敏度约为84%。这种闪烁扫描术应用于确诊或高度疑似神经内分泌胃肠胰肿瘤的原发肿瘤定位、分期及病程监测。此外，还展示了术中使用γ探测器进行肿瘤定位。由于肿瘤摄取具有高度选择性，因此使用放射性标记的生长抑素类似物进行治疗应是可行的。研发最佳示踪剂是当前研究的课题。
