Röschke J, Prentice-Cuntz T, Wagner P, Mann K, Frank C
Department of Psychiatry, University of Mainz, Germany.
Biol Psychiatry. 1996 Oct 15;40(8):736-43. doi: 10.1016/0006-3223(95)00495-5.
Classical analysis of the spontaneous sleep EEG in depressive disorder commonly reveals alterations of sleep continuity, number of awakenings, slow-wave sleep, and REM sleep compared to healthy controls; however, conventional analysis can not help understand dynamic differences of the sleep EEG during different sleep stages. In order to elicit qualitative alterations of information processing between depressives and healthy controls, we measured late components of auditory and visual evoked potentials (AEPs and VEPs) during different sleep stages of 15 depressive inpatients and in a sex- and age-matched control group from scalp positions Fz, Cz and Pz. According to linear system theory, we then computed the amplitude frequency characteristic (AFC) from averaged AEPs and VEPs in different sleep stages. These AFCs describe the input/output relation of the system under study leading to a characterization of the transfer properties of the brain during sleep in depression. Our investigations showed that information processing appears characteristically altered in depression during non-REM sleep for both auditory and visual stimulation compared to healthy controls. The transfer properties for processing auditory as well as visual information during REM sleep do not appear dynamically impaired in depressive disorder.
与健康对照组相比，抑郁症患者自发睡眠脑电图的经典分析通常显示睡眠连续性、觉醒次数、慢波睡眠和快速眼动睡眠存在改变；然而，传统分析无助于理解不同睡眠阶段睡眠脑电图的动态差异。为了揭示抑郁症患者与健康对照组之间信息处理的质性改变，我们在15名抑郁症住院患者以及一个性别和年龄匹配的对照组处于不同睡眠阶段时，从头皮Fz、Cz和Pz位置测量了听觉和视觉诱发电位（AEP和VEP）的晚期成分。然后，根据线性系统理论，我们计算了不同睡眠阶段平均AEP和VEP的振幅频率特性（AFC）。这些AFC描述了所研究系统的输入/输出关系，从而对抑郁症患者睡眠期间大脑的传递特性进行表征。我们的研究表明，与健康对照组相比，抑郁症患者在非快速眼动睡眠期间，听觉和视觉刺激的信息处理均呈现出特征性改变。在抑郁症患者中，快速眼动睡眠期间处理听觉和视觉信息的传递特性并未出现动态受损。
