舍曲林治疗后大鼠脑中谷氨酸脱羧酶mRNA表达的调节

Regulation of glutamic acid decarboxylase mRNA expression in rat brain after sertraline treatment.

作者信息

Giardino L, Zanni M, Bettelli C, Savina M A, Calzà L

机构信息

Inst. of Otolaryngol. II, Milano University, Italy.

出版信息

Eur J Pharmacol. 1996 Sep 26;312(2):183-7. doi: 10.1016/0014-2999(96)00588-2.

DOI:10.1016/0014-2999(96)00588-2

PMID:8894594

Abstract

We now investigated the effect of chronic treatment with sertraline on glutamic acid decarboxylase mRNA expression in different rat brain areas by means of in situ hybridization. We found a reduced glutamic acid decarboxylase mRNA expression in the prefrontal cortex, accumbens nucleus, olfactory tubercle and reticular nucleus of the thalamus. The involvement of presynaptic modulation of gamma-amino-butyric acid transmission in the anxiolytic effect of sertraline is discussed.

摘要

我们现在通过原位杂交研究了舍曲林长期治疗对不同大鼠脑区谷氨酸脱羧酶mRNA表达的影响。我们发现前额叶皮质、伏隔核、嗅结节和丘脑网状核中谷氨酸脱羧酶mRNA表达降低。文中讨论了γ-氨基丁酸传递的突触前调制在舍曲林抗焦虑作用中的参与情况。